Programmed hyperphagia secondary to increased hypothalamic SIRT1
نویسندگان
چکیده
منابع مشابه
Food Intake and Hypothalamic Hyperphagia †
Animals eat different amounts of different diets, which implies that they recognize some quality or qualities of the diet. Both Cowgill' and Adolph1 were aware of this problem, but no one appears to have made a systematic attempt to define the dietary quality recognized by animals. Both of these workers were led to the opinion that their animals seemed to "eat for calories," i.e., for energy. H...
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Experimental study of hypothalamic obesity is based upon a foundation laid by clinicians who described lesions of the hypophysiohypothalamic region in obese human patients. Because of the non-specific character of the lesions which they found, previous investigation was naturally directed toward discovering whether damage to the hypothalamus, to the hypophysis, or to both was necessary to produ...
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BACKGROUND Intrauterine and postnatal overnutrition program hyperphagia, adiposity and glucose intolerance in offspring. Single-nucleotide polymorphisms (SNPs) of the fat mass and obesity associated (FTO) gene have been linked to increased risk of obesity. FTO is highly expressed in hypothalamic regions critical for energy balance and hyperphagic phenotypes were linked with FTO SNPs. As nutriti...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2014
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2014.09.031